| Document
Code: PH A |
| [21] Application Number: | 1-2001-001660 |
| [54] Title: | AZA-BRIDGED-BICYCLIC AMINO ACID DERIVATIVES AS a4 INTEGRIN ANTAGONISTS |
| [72] Inventor(s): |
ALEXEY B DYATKIN, OF , PENNSYLVANIA, UNITED STATES OF AMERICA BRUCE E MARYANOFF, OF , PENNSYLVANIA, UNITED STATES OF AMERICA WILLIAM J HOEKSTRA, OF , NORTH CAROLINA, UNITED STATES OF AMERICA WEI HE, OF , PENNSYLVANIA, UNITED STATES OF AMERICA WILLIAM A KINNEY, OF , PENNSYLVANIA, UNITED STATES OF AMERICA |
| [73] Assignee(s): |
ORTHO MCNEIL PHARMACEUTICAL, INC. , OF NEW JERSEY, UNITED STATES OF AMERICA |
| [74] Attorney/Agent: | ROMULO MABANTA BUENAVENTURA SAYOC & DE LOS ANGELES |
| [22] Date Filed: | 6/29/2001 |
| [30] | Priority Data: | ||||||||
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| [51] International Class: | C07D 451/00 |
| [57] Abstract: |
| The invention is directed to aza-bridged-bicyclic compounds having Formula (I): Formula (I) and a pharmaceutically acceptable salts thereof. The compounds are useful α4 integrin receptor antagonists and in particular, α4β7 integrin receptor antagonists. The invention is further directed to methods for use of instant compounds for treating integrin mediated disorders including, but not limited to, inflammatory disorders, autoimmune disorders and cell-proliferative disorders, methods for preparing the compounds and methods for preparing the intermediates, derivatives and pharmaceutical compositions thereof. |
| Search Report |
| [58] Field of Search: | C07D 451/00 |
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